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In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation.

Thus, estradiol produces breast development, and is responsible for changes in the body shape, affecting bones, joints, and fat deposition.

The major pathway involves the formation of androstenedione, which is then converted by aromatase into estrone and is subsequently converted into estradiol.

Alternatively, androstenedione can be aromatized into testosterone, which can then be converted into estradiol.

(See Hypothalamic–pituitary–gonadal axis.) Estrogen is considered to play a significant role in women’s mental health, with links suggested between the hormone level, mood and well-being.

Sudden drops or fluctuations in, or long periods of sustained low levels of estrogen may be correlated with significant mood-lowering.

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